Resumen
Introducción. La inteligencia artificial (IA) está transformando la práctica médica, ofreciendo nuevas herramientas para mejorar la toma de decisiones clínicas en medicina interna. Esta revisión analiza el estado actual y las perspectivas futuras de la IA como herramienta de apoyo para el médico internista. Objetivo: Evaluar sistemáticamente la evidencia disponible sobre la aplicación de la inteligencia artificial en la toma de decisiones clínicas en medicina interna, identificando beneficios, limitaciones y consideraciones éticas. Metodología: Se realizó una revisión sistemática siguiendo las directrices PRISMA 2020. Se llevó a cabo una búsqueda estructurada en PubMed, Google Académico y bases de datos especializadas, utilizando términos como "artificial intelligence", "internal medicine", "clinical decision support", y "machine learning". Se aplicaron criterios de inclusión específicos para estudios publicados entre 2020-2025. Resultados: La evidencia actual demuestra que los sistemas de IA mejoran significativamente la precisión diagnóstica, optimizan la estratificación de riesgo y facilitan la personalización de tratamientos en medicina interna. Sin embargo, persisten desafíos relacionados con la interpretabilidad, la validación clínica y la integración en flujos de trabajo existentes. Conclusiones: Esta revisión sistemática responde explícitamente la pregunta de investigación: la inteligencia artificial mejora de forma significativa la precisión diagnóstica, optimiza la estratificación de riesgo y personaliza las intervenciones terapéuticas en medicina interna. Su impacto es cuantificable y consistente en las tres dimensiones críticas del razonamiento clínico: diagnóstico, pronóstico y tratamiento. No obstante, su eficacia depende de una implementación supervisada, formación médica especializada y marcos regulatorios claros. La evidencia confirma que la IA es una herramienta complementaria que potencia el juicio clínico del médico internista sin sustituirlo, consolidando su papel como integrador crítico entre la tecnología y la experiencia clínica humana.
Referencias
1. Halpert E, García E, Rodríguez MA. Principios fundamentales de la medicina interna moderna: enfoque integrado del paciente adulto. Rev Med Interna Mex. 2023;39(4):245-253
2. Patel VL, Arocha JF, Zhang J. Thinking and reasoning in medicine. In: Holyoak KJ, Morrison RG, editors. The Cambridge handbook of thinking and reasoning. Cambridge: Cambridge University Press; 2021. p. 727-750
3. Rajkomar A, Dean J, Kohane I. Machine learning in medicine. N Engl J Med. 2019;380(14):1347- 1358
4. Liu X, Faes L, Kale AU, Wagner SK, Fu DJ, Bruynseels A, et al. A comparison of deep learning performance against health-care professionals in detecting diseases from medical imaging: a systematic review and meta-analysis. Lancet Digit Health. 2019;1(6):e271-e297
5. Barnett K, Mercer SW, Norbury M, Watt G, Wyke S, Guthrie B. Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study. Lancet. 2012;380(9836):37-43
6. Comisión Nacional de Arbitraje Médico. Lineamientos para el uso de inteligencia artificial en la práctica médica. Rev CONAMED. 2024;29(2):89-97
7. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71
8. Shea BJ, Reeves BC, Wells G, Thuku M, Hamel C, Moran J, et al. AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both. BMJ. 2017;358:j4008
9. Attia ZI, Kapa S, Lopez-Jimenez F, McKie PM, Ladewig DJ, Satam G, et al. Screening for cardiac contractile dysfunction using an artificial intelligence-enabled electrocardiogram. Nat Med. 2019;25(1):70-74
10. Shimabukuro DW, Barton CW, Feldman MD, Mataraso SJ, Das R. Effect of a machine learningbased severe sepsis prediction algorithm on patient survival and hospital length of stay: a randomised clinical trial. BMJ Open Respir Res. 2017;4(1):e000234
11. Wang Y, Wang L, Rastegar-Mojarad M, Moon S, Shen F, Afzal N, et al. Clinical information extraction applications: a literature review. J Biomed Inform. 2018;77:34-49
12. Gulshan V, Peng L, Coram M, Stumpe MC, Wu D, Narayanaswamy A, et al. Development and validation of a deep learning algorithm for detection of diabetic retinopathy in retinal fundus photographs. JAMA. 2016;316(22):2402-2410
13. Obermeyer Z, Emanuel EJ. Predicting the future - big data, machine learning, and clinical medicine. N Engl J Med. 2016;375(13):1216- 1219
14. Zhu Y, Peng M, Wang H, Tang Y, Wang G. Machine learning in heart failure diagnosis, risk stratification, and treatment. Curr Opin Cardiol. 2023;38(2):152-159
15. Escobar GJ, Liu VX, Schuler A, Lawson B, Greene JD, Kipnis P. Automated identification of adults at risk for in-hospital clinical deterioration. N Engl J Med. 2020;383(20):1951-1960
16. Yu KH, Beam AL, Kohane IS. Artificial intelligence in healthcare. Nat Biomed Eng. 2018;2(10):719-731
17. Tyler NS, Jacobs PG. Artificial pancreas systems for the treatment of diabetes. Annu Rev Control. 2020;50:1-10
18. Su C, Xu Z, Pathak J, Wang F. Deep learning in mental health outcome research: a scoping review. Transl Psychiatry. 2020;10(1):116
19. Sharabiani MT, Aylin P, Bottle A. Systematic review of comorbidity indices for administrative data. Med Care. 2012;50(12):1109-1118
20. Chen JH, Asch SM. Machine learning and prediction in medicine - beyond the peak of inflated expectations. N Engl J Med. 2017;376(26):2507-2509
21. Sutton RT, Pincock D, Baumgart DC, Sadowski DC, Fedorak RN, Kroeker KI. An overview of clinical decision support systems: benefits, risks, and strategies for success. NPJ Digit Med. 2020;3:17
22. Liu Y, Chen PC, Krause J, Peng L. How to read articles that use machine learning: users' guides to the medical literature. JAMA. 2019;322(18):1806-1816
23. Goddard K, Roudsari A, Wyatt JC. Automation bias: a systematic review of frequency, effect mediators, and mitigators. J Am Med Inform Assoc. 2012;19(1):121-127
24. Obermeyer Z, Powers B, Vogeli C, Mullainathan S. Dissecting racial bias in an algorithm used to manage the health of populations. Science. 2019;366(6464):447-453
25. Sendak MP, Ratliff W, Sarro D, Alderton E, Futoma J, Gao M, et al. Real-world integration of a sepsis deep learning technology into routine clinical care: implementation study. JMIR Med Inform. 2020;8(7):e15182
26. Cresswell K, Majeed A, Bates DW, Sheikh A. Computerised decision support systems for healthcare professionals: an interpretative review. Inform Prim Care. 2012;20(2):115-128
27. Price WN, Cohen IG. Privacy in the age of medical big data. Nat Med. 2019;25(1):37-43
28. McCoy LG, Nagaraj S, Morgado F, Harish V, Das S, Celi LA. What do medical students actually need to know about artificial intelligence? NPJ Digit Med. 2020;3:86
29. Paranjape K, Schinkel M, Nannan Panday R, Car J, Nanayakkara P. Introducing artificial intelligence training in medical education. JMIR Med Educ. 2019;5(2):e16048
30. Thirunavukarasu AJ, Ting DSJ, Elangovan K, Gutierrez L, Tan TF, Ting DSW. Large language models in medicine. Nat Med. 2023;29(8):1930- 1940
31. Topol EJ. High-performance medicine: the convergence of human and artificial intelligence. Nat Med. 2019;25(1):44-56
32. Li T, Sahu AK, Talwalkar A, Smith V. Federated learning: challenges, methods, and future directions IEEE Signal Process Mag. 2020;37(3):50-60
33. Cabitza F, Rasoini R, Gensini GF. Unintended consequences of machine learning in medicine. JAMA. 2017;318(6):517-518
34. Char DS, Shah NH, Magnus D. Implementing machine learning in health care - addressing ethical challenges. N Engl J Med. 2018;378(11):981-983
35. Martínez-García A, Reyes-Zurita FJ, PerandrésLópez C, Alba E. The role of artificial intelligence in clinical practice: current evidence and future perspectives. Rev Clin Esp. 2021;221(4):236-244
36. Rajkomar A, Hardt M, Howell MD, Corrado G, Chin MH. Ensuring fairness in machine learning to advance health equity. Ann Intern Med. 2018;169(12):866-872
37. Vayena E, Blasimme A, Cohen IG. Machine learning in medicine: addressing ethical challenges. PLoS Med. 2018;15(11):e1002689
38. Shortliffe EH, Sepúlveda MJ. Clinical decision support in the era of artificial intelligence. JAMA. 2018;320(21):2199-2200
39. Mandel JC, Kreda DA, Mandl KD, Kohane IS, Ramoni RB. SMART on FHIR: a standards-based, interoperable apps platform for electronic health records. J Am Med Inform Assoc. 2016;23(5):899-908
40. Wartman SA, Combs CD. Medical education must move from the information age to the age of artificial intelligence. Acad Med. 2018;93(8):1107-1109
41. Sapci AH, Sapci HA. Artificial intelligence education and tools for medical and health informatics students: systematic review. JMIR Med Educ. 2020;6(1): e19285
42. He J, Baxter SL, Xu J, Xu J, Zhou X, Zhang K. The practical implementation of artificial intelligence technologies in medicine. Nat Med. 2019;25(1):30-36
43. Singh H, Sittig DF. Advancing the science of measurement of diagnostic errors in healthcare: the Safer Dx framework. BMJ Qual Saf. 2015;24(2):103-110

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